Methods
The method has previously been described in detail [5,6]. In short, the 16 patients, all with BMI>30 kg/m2, free of
thyroid cardiac and renal disease – were advised to follow a diet containing initially 1800 kcal for men and 1600 kcal for women. The proportions of carbohydrates, fat and protein were 20%, 50% and 30% respectively. The daily quantity of carbohydrates was 80–90 g. The recommended carbohydrate consumption was limited to vegetables and salad. Instead of ordinary bread crisp/hard bread was recommended, each slice containing 3.5 to 8 g carbohydrates.