The mitochondria undergo sequential changes that include contraction or condensation of the inner membrane and dissipation of matrical granules (C phase), inner membrane swelling and cristaeolysis (S phase), formation of flocculent aggregates, and then disintegration (27). The molecular mechanisms for the changes in organelle structure that occur during necrotic cell death still have not been identified. Some of these organelle abnormalities are reversible, if homeostasis is restored early enough (28).