While the diagnosis a posteriori of an empty sella has no clinical consequences, the early diagnosis of Sheehan's syndrome may be important to establish the best therapeutic approach. Hypophysitis and necrosis of a macroadenoma are the two most critical alternative diagnoses to consider, with immediate therapeutic implications including:
High-dose corticotherapy is sometimes indicated in both hypophysitis [ 16] and apoplexy [ 13], but never discussed in Sheehan's syndrome.