4. Discussion
Wound healing involves a sequence of molecular and cellular
events including inflammation, cell migration, angiogenesis,
extracellular matrix synthesis, and re-epithelialization. Principally,
inflammation is a protective response to eliminate the initial cause
of cell injury as well as necrotic cells and tissues resulting from the
original insult; however, inflammation is an integral stage ofwound
healing process. The inflammatory response is terminated when
the injuries stimulus is removed and the inflammatory mediators
have been dissipated, catabolized or inhibited.Recruited inflammatory
cells not only clean up the necrotic debris but also elaborate
mediators that drive the synthesis of newECM. Thus, healing begins
very early in the process of inflammation (Martin et al., 1992).