The goats were individually housed in a metabolic cage and fed adlibitum with a diet consisting of bermuda grass and commercial concentrate mix (6:4, wt/wt). Dry matter intake, ADG,nutrients digestibility, hematological parameters, and behavioral activities of the goats were measured before and after vaccination. Although DMI was not decreased(P > 0.05), ADG was decreased by the vaccination to the goats (P < 0.01).