The total number of leukocytes was increased while that of erythrocytes was decreased by the FMD vaccination (P < 0.01). The vaccination shortened standing time while extended lying time and the time spent in drinking (P < 0.05). The treatment by CADI reduced the adverse effect of vaccination on ADG and goat behavior compared with control and GABA treatment (P < 0.05).We concluded that the FMD vaccination decreased ADG of the goats without depression of diet intake,and CADI may attenuate the adverse effect of the FMD vaccination.