We sought to determine whether sensitization to specific
aeroallergens modifies AR symptom severity. To address this in
the most controlled manner possible, we took advantage of 4
separate aeroallergen exposure studies previously conducted in an
allergen challenge chamber (ACC). In these studies allergic
adults volunteered for challenges to indoor or outdoor aeroallergens
(HDMs, mountain cedar, Virginia live oak [VLO], and
ragweed pollens).6-8 Confounding factors were mitigated by 2
conditions. First, specific concentrations of the aeroallergens
were delivered in a highly controlled environment, which elicited