of surfactant production and secretion in sinonasal mucosa
indicates that initial contact and interaction between pathogens
and SPs occurs after inhalation and deposition into the
mucus of the upper respiratory tract.
This study characterizes the differential expression of SP-A
in the nasal mucosal samples of patients with CRS using
immunohistochemical staining and quantitative PCR. By
immunohistochemistry, we detected strong SP-A staining in
the epithelial cells and lumen of the submucosal glands in the
CRS patients. Also SP-A mRNA increased significantly in CRS
patients and decreased significantly in patients with PAR.