The second limitation is the short duration of supplementation and follow-up, hampering a realistic judgment on the long-term efficacy of curcuminoids. Third, only a single dose of curcuminoids was tested in the present study, and it remains to be identified if the observed effects of curcuminoids in OA patients follow a dose–response pattern. Finally, the study population of the present trial was limited to patientswithmild tomoderate degrees of OA; thus, the relevance of supplementation with curcuminoids in severe cases of OA remains elusive