#1: The golden rule – SAVE OFTEN!
Dishonored allows you to save anytime you’re not in combat or a cutscene. And you should. A lot. If you’re going for total stealth and no kills, especially, you’ll want to save before any major areas with multiple guards. One slipup or one guard you didn’t know was there can set you back quite a bit of playtime if you haven’t been saving frequently.