Prostaglandin E2 (PGE2), the most relevant eicosanoid promoting inflammation and
tumorigenesis, is formed by cyclooxygenases (COXs) and PGE2 synthases from free arachidonic
acid. Preparations of the leaves of Salvia officinalis are commonly used in folk medicine as an
effective antiseptic and anti-inflammatory remedy and possess anticancer activity. Here, we