Regarding DNA biosensors, many studies on ISFET coupled with electronic aptamer-based (EBA) sensors have been reported [34]. Aptamers are nucleic acids (DNA or RNA [ribonucleic acid)] or peptide that selectively bind to their specific target molecules such as small molecules, nucleic acids, proteins, and even cells [35–37]. An ISFET-based aptamer sensor also uses a label-free electrochemical detection technology, measuring the changes in electrochemical signals generated from the interaction between the target molecules and the aptamers.