This meta-analysis of family high-risk studies of
SMI found that familial transmission of risk is only
partly diagnosis specific. As a result, the total risk of
SMI and any mental illness in offspring of parents with
psychotic or major mood disorders are higher than
previously thought. This should be reflected in genetic
counseling and information provided by clinicians.
Cross-diagnostic research may be needed to advance
the knowledge of etiology and plan effective preventive
interventions.