The reports concerned with the wound-healing effect of aloe in experimental animals or humans have been contradictory. In one such study, the incision wounds in rats were rapidly healed by aloe gel and the effect was attributed to more rapid maturation of collagen5. Other researchers have suggested that aloe increases the oxygen access of tissues as a result of an increased blood supply9 and others have suggested that aloe stimulates fibroblast activity and collagen proliferation10. Mannose-6-phosphate was identified as a cause of significant wound healing by aloe11, and the healing by aloe was found to be accompanied by higher levels of hyaluronic acid and dermatan sulfate, which were suggested to stimulate collagen synthesis and fibroblast activity12.