To evaluate the analytical application of the developed method,
the effects of some common inorganic ions present in real samples
were investigated on the determination of 1 mg L1 cloxacillin
sodium. The tolerance limit of each foreign species was taken as
the amount, which caused a relative error of less than 5% in the
CL signal for the determination of cloxacillin sodium. Thus, the
effect of potential interfering substances was examined and the
results are given in Table 3. As shown in Table 3, most anionic
and cationic ions do not interfere with the determination of
1.00 mg L1. However, 1-fold Cu2+ interfered. The interference
from this metal ion could be removed with the addition of ethylenediaminetetraacetic
acid (EDTA) and/or passing the sample solution
through a cation exchanger column. Also, EDTA with
concentration up to 20 times greater than cloxacillin sodium had
negligible effect on the CL signal. It can be concluded that the current
CL method presented high selectivity and could be applied to
the determination of cloxacillin sodium in environmental water
samples and pharmaceutical preparation.
To evaluate the analytical application of the developed method,the effects of some common inorganic ions present in real sampleswere investigated on the determination of 1 mg L1 cloxacillinsodium. The tolerance limit of each foreign species was taken asthe amount, which caused a relative error of less than 5% in theCL signal for the determination of cloxacillin sodium. Thus, theeffect of potential interfering substances was examined and theresults are given in Table 3. As shown in Table 3, most anionicand cationic ions do not interfere with the determination of1.00 mg L1. However, 1-fold Cu2+ interfered. The interferencefrom this metal ion could be removed with the addition of ethylenediaminetetraaceticacid (EDTA) and/or passing the sample solutionthrough a cation exchanger column. Also, EDTA withconcentration up to 20 times greater than cloxacillin sodium hadnegligible effect on the CL signal. It can be concluded that the currentCL method presented high selectivity and could be applied tothe determination of cloxacillin sodium in environmental watersamples and pharmaceutical preparation.
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