The robust control structure is designed by combining a linearizing control law with an interval observer able to estimates a lower and an upper bound of unmeasurable states. Also, the uncertain process parameters are replaced by their lower and upper bounds assumed known. The robust-adaptive controller uses a linearizing control law coupled with an interval observer for the unmeasured states, and with a parameter estimator. These approaches are applied to a particular wastewater treatment bioprocess based on anaerobic fermentation. The effectiveness of the proposed algorithms is validated by several numerical simulations.