Abstract: In spite of advances in invertebrate pest management, the agricultural industry is
suffering from impeded pest control exacerbated by global climate changes that have altered
rain patterns to favour opportunistic breeding. Thus, novel naturally derived chemical
compounds toxic to both terrestrial and aquatic invertebrates are of interest, as potential
pesticides. In this regard, marine cyanobacterium-derived metabolites that are toxic to both
terrestrial and aquatic invertebrates continue to be a promising, but neglected, source of
potential pesticides. A PubMed query combined with hand-curation of the information from
retrieved articles allowed for the identification of 36 cyanobacteria-derived chemical
compounds experimentally confirmed as being toxic to invertebrates. These compounds are
discussed in this review.