Transfusion therapy is not currently a routine treatment approach for patients with TI. Initiating regular blood transfusions in such patients remains a hard decision because of the heterogeneity of the disease. Patients who would benefit from such a measure include those with delayed growth, recurrent infections, and hypersplenism [2,3]. When given, blood transfusions should be leukocyte-poor to avoid sensitization, keeping in mind that such patients might become transfusion-dependent in the future. The physiologic anemia of pregnancy secondary to the increase in the fluid component of the blood is aggravated in patients with TI. Also, the greater demand for hemoglobin for normal growth and development of the fetus might necessitate initiating transfusion or increasing the number of transfusions in those already requiring it. A study published in the late 1980s found that Hb levels in patients with TI gradually decrease in the first and second trimesters, to increase again in the third trimester [10].
Transfusion therapy is not currently a routine treatment approach for patients with TI. Initiating regular blood transfusions in such patients remains a hard decision because of the heterogeneity of the disease. Patients who would benefit from such a measure include those with delayed growth, recurrent infections, and hypersplenism [2,3]. When given, blood transfusions should be leukocyte-poor to avoid sensitization, keeping in mind that such patients might become transfusion-dependent in the future. The physiologic anemia of pregnancy secondary to the increase in the fluid component of the blood is aggravated in patients with TI. Also, the greater demand for hemoglobin for normal growth and development of the fetus might necessitate initiating transfusion or increasing the number of transfusions in those already requiring it. A study published in the late 1980s found that Hb levels in patients with TI gradually decrease in the first and second trimesters, to increase again in the third trimester [10].
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