In conclusion, the work demonstrated for the first time an
ability of ionic F to induce premature death of erythrocytes
and increase their susceptibility to senescence under in vivo
conditions. These results well agree with the data obtained
earlier in our in vitro studies [15, 16]. However, it is important
that apoptotic erythrocyte death observed in this study
occur at much lower F concentrations (20 ppm F in drinking
water yields ~6 μM of ionic F in the rat plasma) than that
observed under in vitro conditions. Most probably, such
effects are due to a permanent cumulative effect of F on
the rat erythrocytes and hematopoietic processes.
Acknowledgment The work was performed with financial support
from the Russian Fund of Basic Investigations (project 09-04-01679a).
Conflict of Interests The authors declare no conflict of interests.