It is notable that the majority of the most-often cited studies were
excluded from the analysis. Does this mean that the traditional
statement that a sealant is effective as long as it remains attached to
the tooth is no longer valid? The answer from this well-designed
systematic review is that the evidence supporting this theory in not as
solid as we thought. We need more high-quality clinical trials,
although the sealants are still recommended for the prevention of
caries in permanent first molars.