Inference of Substitution Rates and Dates of Divergence
The posterior mean substitution rates inferred for DENV-1 to DENV-4 under the relaxed clockmodel are shown in table
2, along with the inferred date for the most recent common ancestor (MRCA) of each genotype in the Americas.
The mean substitution rates for the four genotypes were very similar, ranging from 7.8 104 subs/site/year to 9.9
104 subs/site/year, with overlaps among the four pairs of the 95% highest posterior density (HPD) intervals. The date
that the MRCA of each genotype was estimated to have existed was prior to the year that genotype was first reported
in the Americas. Only in the case of DENV-2 did the 95% HPD intervals for the time of the MRCA include the year
of first detection