Apigenin has been shown to prevent renal damage caused by cyclosporin in rats, associated with reduced expression of the cell death mediator bcl-2 in histopathological sections.[5] Cyclosporine A enhances the expression of transforming growth factor-β in the rat kidney, which signifies accelerated apoptosis. Therefore, transforming growth factor-β and apoptotic index may be used to assess apigenin and its effect on cyclosporine A-induced renal damage