If Yaz is taken with certain drugs and foods, the effects of the pills could be altered. Always check with a doctor before taking the following drugs: ACE inhibitors, antibiotics, heparin, morphine, diuretics, salicylic acid, St. John’s wort and vitamin C. Women who take long-term NSAIDs, such as ibuprofen and naproxen, should not take Yaz. Women who have ever had blood clots in the legs, lungs or eyes should not take Yaz. Yaz is known to increase the risk of severe and deadly blood clots.