Introduction
For many years, bipolar disorder (BD) was not believed to be associated with durable cognitive problems. A return to normal cognitive function was believed to be one of the main distinguishing features of BD compared with schizophrenia. However, over the past 15 years, scores of studies have accumulated to indicate that BD is associated with clinically significant cognitive impairments evident both during mood episodes and during clinically euthymic periods. Collectively, depressive symptoms and cognitive impairment account for most of the disability produced by BD. There remains a great need for efficacious treatments targeting either bipolar depression or cognitive dysfunction. Emerging research has shifted away from efforts to parse cognitive deficits from mood symptoms toward examining their shared neurobiological mechanisms, behavioral determinants, and treatment avenues.
IntroductionFor many years, bipolar disorder (BD) was not believed to be associated with durable cognitive problems. A return to normal cognitive function was believed to be one of the main distinguishing features of BD compared with schizophrenia. However, over the past 15 years, scores of studies have accumulated to indicate that BD is associated with clinically significant cognitive impairments evident both during mood episodes and during clinically euthymic periods. Collectively, depressive symptoms and cognitive impairment account for most of the disability produced by BD. There remains a great need for efficacious treatments targeting either bipolar depression or cognitive dysfunction. Emerging research has shifted away from efforts to parse cognitive deficits from mood symptoms toward examining their shared neurobiological mechanisms, behavioral determinants, and treatment avenues.
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