We developed a novel web-based tool that pipelines the informatics process for pedigree data. PedWiz may be accessed at http://darwin.cwru.edu/~song/pedwiz. Here we present an application example using pedigree data from the Madeline 2.0 website (Trager et al., 2007). These pedigree data contain a consanguineous marriage between cousins. The user inputs configuration information and the location of the pedigree file through the interface on the website as shown in