The most common cause of death is cardiac failure resulting from transfusional iron overload.4,5 However, as chelation
therapies have improved, subjects are living longer and nutritional status is becoming increasingly important. Patients
with thalassemia commonly exhibit inadequate growth, poor immune function, increased oxidative stress, and decreased
bone mineralization, all morbidities with links to poor nutritional status.6-8Recently, it has been shown that subjects with
thalassemia have reduced body fat and lean mass and that these alterations in body composition are related to both reduced
growth and decreased bone density.9 In addition, Claster and colleagues reported that more than half of a sam
The most common cause of death is cardiac failure resulting from transfusional iron overload.4,5 However, as chelationtherapies have improved, subjects are living longer and nutritional status is becoming increasingly important. Patientswith thalassemia commonly exhibit inadequate growth, poor immune function, increased oxidative stress, and decreasedbone mineralization, all morbidities with links to poor nutritional status.6-8Recently, it has been shown that subjects withthalassemia have reduced body fat and lean mass and that these alterations in body composition are related to both reducedgrowth and decreased bone density.9 In addition, Claster and colleagues reported that more than half of a sam
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