(at least 2 out of 3) are obese [3–5]. OSA is a chronic progressive dis- ease and particularly the more severe stages of OSA have been linked to an increased risk for cardiovascular morbidity and mortal- ity [6,7]. In the first randomized study conducted on the effects of weight loss on OSA, we demonstrated that a 1-year lifestyle inter- vention, which included an early weight reduction program, repre- sented a feasible and effective treatment for overweight and obese participants with mild OSA [8]. These findings have been subse- quently confirmed by two randomized studies, one conducted in obese OSA patients with type two diabetes mellitus (DM) and the