(RR 2.7; p <0.0001), diabetesmellitus (RR 1.6; p =0.002) andfemale gender (RR 1.5; p =0.007). Risk factors associatedwith medication were number of concurrently administeredpotassium-increasing drugs (RR 3.3 per additional drug; p <0.0001) and longer duration of the DDI (RR 4.9 for duration≥6 days; p <0.0001). Physician-related factors associated withthe development of hyperkalaemia were undetermined orelevated serum potassium level before treatment initiation(RR 2.2; p <0.001) and infrequent monitoring of serumpotassium during a DDI (interval >48 h: RR 1.6; p <0.01).Conclusion Strategies for reducing the risk of hyperkalaemiaduring potassium-increasing DDIs should consider bothpatient- and physician-related risk factors.Keywords Drug–drug interactions . Hyperkalaemia .Monitoring . Potassium . Risk factorsIntroduction
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