Extraction efficiencies of the targeted chemicals and materials combinations as defined as the% ratio of chemical mass recovered from a coupon over theoretical chemical mass applied ranged from 70% (carbaryl) to 107% (malathion) with a less than 30% variance across replicate chemical/material combinations. Although it would be more desirable to obtain extraction efficiencies closer to 100% and with higher precision, the impact on the calculated decontamination efficacy values is essentially none existent as the extraction efficiency value applies to the extraction of both positive controls and test coupons. The absolute extraction efficiency is also negated in the calculation of the decontamination efficacy value. In this study, preference was given to a common extraction method that was suitable for sufficient extraction of all chemicals from all materials over a tailored chemical/material extraction approach. The only exception to this commonality was the use of two extraction solvents (hexane, methanol, or isopropanol), depending on observed material incompatibilities when sonicating a material in a solvent for 10 min.