A patient with Pulmonary hypertension has a resting MPAP >25 mmHg, with a pulmonary capillary wedge pressure (PCWP) 15 mmHg. As the disease progresses, right ventricular hypertrophy occurs as a result of the increased pulmonary vascular resistance (PVR), which leads to right heart failure, activity intolerance, and eventually can lead to death. Signs and symptoms of Pulmonary hypertension are related to the severity of right heart failure. In the early stages of the disease, the patient may be asymptomatic. With progression of right heart failure, the patient may present with peripheral edema, ascites, hepatomegaly, anorexia, exercise intolerance, and progressive dyspnea from decreased cardiac output (CO).