Received 31 August 2015Accepted 2 September 2015Available online 9 September 2015Keywords:AgricultureBiotechnologydsRNAGMORNAiToxicology ForumDuring the 40th Annual Meeting of The Toxicology Forum, the current and potential future science,regulations, and politics of agricultural biotechnology were presented and discussed. The meeting ses-sion described herein focused on the technology of RNA interference (RNAi) in agriculture. The generalprocess by which RNAi works, currently registered RNAi-based plant traits, example RNAi-based traits indevelopment, potential use of double stranded RNA (dsRNA) as topically applied pesticide active in-gredients, research related to the safety of RNAi, biological barriers to ingested dsRNA, recent regulatoryRNAi science reviews, and regulatory considerations related to the use of RNAi in agriculture were dis-cussed. Participants generally agreed that the current regulatory framework is robust and appropriate forevaluating the safety of RNAi employed in agricultural biotechnology and were also supportive of the useof RNAi to develop improved crop traits. However, as with any emerging technology, the potential rangeof future products, potential future regulatory frameworks, and public acceptance of the technology willcontinue to evolve. As such, continuing dialogue was encouraged to promote education of consumersand science-based regulations.