Pretreatment is the first challenge for obtaining potential fermentable sugars digestibility from lignocellulosic biomass [17]. Not only in the level of component but also in the levels of tissue and cell, the heterogeneity and recalcitrance to conversion are shown in Table 1 and Table 2. There is still a certain bottleneck facing its large-scale conversion [18], [19] and [20]. To deconstruct the bottleneck, increase the surface area and porosity of the substrate, and make cellulose more accessible to hydrolytic enzymes, a number of pretreatment methods have been developed, which can be roughly classified into physical, physico-chemical, chemical and biological pretreatment [17], [21], [22], [23] and [24]. Mood et al reviewed the diverse advantages and drawbacks associated with each pretreatment method [14]. According to relevant literature, the overall efficiency of the pretreatment was a good balance between inhibitors formation and substrate digestibility [25], [26] and [27]. Moreover, pretreatment has also been viewed as one of the main economic costs for obtaining potential fermentable sugars [28] and [29]. Therefore, an efficient and economic pretreatment with low inhibitor concentration is essential for its commercialization.