Enoate reductases (EREDs) are NAD(P)H-dependent oxidoreductases
that contain flavin mononucleotide (FMN), which catalyze
the stereo- and enantioselective reduction of a,b-unsaturated
ketones, aldehydes, nitro alkenes, and carboxylic acids.[1]
Christian and Warburg discovered the first ERED in bottom-fermented
yeast and gave it the well-known name “yellow
enzyme”.[2] Later they found another yellow enzyme, and the
first enoate reductase was redefined as the “old yellow
enzyme” (OYE), which is still used as a term for the ERED
enzyme family. Since then various other enzymes from bacteria,
yeast, plants, and eukaryotes have been described
Enoate reductases (EREDs) are NAD(P)H-dependent oxidoreductasesthat contain flavin mononucleotide (FMN), which catalyzethe stereo- and enantioselective reduction of a,b-unsaturatedketones, aldehydes, nitro alkenes, and carboxylic acids.[1]Christian and Warburg discovered the first ERED in bottom-fermentedyeast and gave it the well-known name “yellowenzyme”.[2] Later they found another yellow enzyme, and thefirst enoate reductase was redefined as the “old yellowenzyme” (OYE), which is still used as a term for the EREDenzyme family. Since then various other enzymes from bacteria,yeast, plants, and eukaryotes have been described
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