and resilient skin.38 In clinical practice, “to look better” doesn’t mean to “look younger.” That is why it is so important to under- stand patients’ wishes and to orientate them to the treatment modality that will give the most satisfying results whereas know- ing all available treatment techniques.39 The age, previous proce- dures or surgery, general health status, type of the skin, style of life and many other factors should be taken into consideration before choosing the strategy for the individual case. The desired therapeutic anti-aging effect of the skin is continuous, step-by step process, which combines various methods of the skin bio- revitalization and rejuvenation, augmentation, restoration of each skin layer individually and in the light of many other fac- tors—from a style of the life to the immune, genetic, emotional and health status in general. This review will emphasize the most important topical and systemic therapeutic agents and trends in the use of invasive procedures.