Background: The presentstudyaimedtoevaluatetherelationshipbetweenthefunctioningofthehy-
pothalamic–pituitary–adrenal (HPA)axisandmajordepressiveepisodesintheremotepostpartum
period.
Methods: The sample(meanage,28.075.3 years)consistedof37depressedpostpartumwomen(DPP),
42 euthymicpostpartumwomen(EPP)and25non-postpartumhealthywomen(HC).Salivarycortisol
samples werecollectedimmediatelyafterawakeningand30min,3and12hlater,atapproximatelythe
sixth monthpostpartum(mean,169.6760.3 days).
Results: Differencesincortisollevelswereobservedatawakening(DPPoEPP¼HC), at30min
(DPPoEPPoHC), at3h(DPP¼EPPoHC) andat12h(DPP4EPP¼HC). Therelativeincrementinthe
cortisol awakeningresponse(CARi%)wassignificantly higherinHC(113.5794.3) thaninEPP
(63.1769.8) andDPP(32.2749.6).Therelativereductionindiurnalvariation(DVr%)waslowerinDPP
(56.5741.8)thaninEPP(75.6722.4) andHC(75.1713.0).
Limitations: The mainlimitationwascortisolcollectiononasingledayandwithoutmeasurementat
midnight.
Conclusions: Our findings suggestthattheremotepostpartumperiodinvolvesattenuationofHPAaxis
reactivity;thisdysregulationismorepronouncedinthepresenceofDPP,whichisassociatedwitha
reduction incortisoldiurnalvariation.Abnormalitiesintheneuroendocrinesystemrelatedtostress
processing, presentevenseveralmonthsafterdelivery,canrepresentvulnerabilitytomentaldisorders.
Thus, improvementsinthementalhealthcareofpostpartumwomenareneeded.
พื้นหลัง: presentstudyaimedtoevaluatetherelationshipbetweenthefunctioningofthehy-axisandmajordepressiveepisodesintheremotepostpartum pothalamic – ต่อมใต้สมอง – ต่อมหมวกไต (พะ)รอบระยะเวลาวิธีการ: ตัวอย่าง (meanage, 28.075.3 years)consistedof37depressedpostpartumwomen(DPP)42 euthymicpostpartumwomen(EPP)and25non-postpartumhealthywomen(HC) Salivarycortisolตัวอย่าง werecollectedimmediatelyafterawakeningand30min, 3and12hlater, atapproximatelytheหก monthpostpartum (หมายถึง 169.6760.3 วัน)ผลลัพธ์: Differencesincortisollevelswereobservedatawakening(DPPoEPP¼HC), at30min(DPPoEPPoHC), at3h(DPP¼EPPoHC) andat12h(DPP4EPP¼HC) Therelativeincrementintheคอร์ติซอ awakeningresponse (CARi %) wassignificantly higherinHC(113.5794.3) thaninEPP(63.1769.8) andDPP(32.2749.6) WaslowerinDPP Therelativereductionindiurnalvariation (DVr %)(56.5741.8)thaninEPP(75.6722.4) andHC(75.1713.0)ข้อจำกัด: mainlimitationwascortisolcollectiononasingledayandwithoutmeasurementatเที่ยงคืนสรุป: suggestthattheremotepostpartumperiodinvolvesattenuationofHPAaxis ผลการวิจัยของเราเกิดปฏิกิริยา thisdysregulationismorepronouncedinthepresenceofDPP, whichisassociatedwithaincortisoldiurnalvariation ลด Abnormalitiesintheneuroendocrinesystemrelatedtostressการประมวลผล presentevenseveralmonthsafterdelivery, canrepresentvulnerabilitytomentaldisordersดังนั้น improvementsinthementalhealthcareofpostpartumwomenareneeded
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