The best way to start off right and ensure you have a smooth ride, and to anticipate problems that may occur, is to prepare and pack for your trip, bringing water, extra clothing, a map of the area you're driving, or other items that might be necessary, depending on your trip. You should also be sure you have some safety basics, particularly a first-aid kit, and a charged mobile phone if possible.
It is also important to make sure that your bike is well-maintained and checked, and that all fluids and major systems, including braking and lights, are in working order. You cannot predict and prevent all vehicle failures and breakdowns, but you can reduce the risk by maintaining your motorcycle.
Next, you will need to make sure that you, as the driver, and any passengers are properly seated on the bike. This means sitting squarely on the center of the seat with feet on footpegs and hands holding handlebars or the rider. Also, make sure you and passengers are always wearing protective helmets. It may not be the law in every state, but it is common sense for safety.