Antibiotic
therapy
alone fails to clear the infection in a significant
fraction of patients (∼20–30%), and each round of antibiotic
treatment
for
CDI further increases the risk of recurrence by
approximately
20% [15]. The reason for recurrence of CDI may
be
failure to clear the C. difficile spores with antibiotic treatment,
which
further suppresses the normal microbiota and perpetuates
theunderlyingproblem.Ultimately,asignificantfractionof