Nonlinear-Mixed Effects Techniques
SimBiology provides nonlinear mixed-effects (NLME) methods to simultaneously fit population data. The following NLME algorithms are included:
Stochastic Approximation Expectation-Maximization (SAEM)
First-order conditional estimate (FOCE)
First-order estimate (FO)
Linear mixed-effects approximation (LME)
Restricted LME approximation (RELME)