There was no significant difference between the temperature decrease following ibuprofen and
acetaminophen administration one, two, and four hours after the drug administration (P =0.055, P = 0.181, and P = 0.0167, respectively), but the difference was significant after 6, 12, and 24 hours (P value of 0.006, 0.044, and 0.005, respectively). No serious or important adverse effect was reported in patients.