Toxicity
Under the guidelines of California Proposition 65, orally ingested non-decolorized aloe vera leaf extract has been listed by the OEHHA, along with goldenseal, among "chemicals known to the state to cause cancer or reproductive toxicity".[62]
Use of topical aloe vera is not associated with significant side effects.[53] Oral ingestion of aloe vera, however, may cause abdominal cramps and diarrhea which in turn can decrease the absorption of drugs.[53] IARC studies have found ingested non-decolorized liquid aloe vera[63] to be carcinogenic in animals, and state that it is a possible carcinogen in humans as well.[64]