Results: Alcohol caused a marked rise in serum alanine aminotransferase (ALT), aspartate
aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase
(gGT) activities. Concerning oxidative stress and antioxidant defense system, the depleted
hepatic glutathione content, glutathione-S-transferase and catalase activities of alcoholadministered
rats were potentially increased above normal levels as a result of pretreatment
with pumpkin oil. However, while elevated lipid peroxidation was noticed in alcohol
treated rats, pretreatment with pumpkin oil produced a detectable decrease in lipid peroxidation
level