Computer vision syndrome is an array of disorders, which encompass ocular, musculoskeletal, dermatological as well as psychological adverse effects among the users of Visual display units in either form. To summarize, appropriate refraction aids, use of higher frequency and higher resolution LED monitors, screen filters, improving the ambient lighting facility, modifying the ergonomic placement of monitors may ameliorate asthe- nopic component; computer peripheral adjustments like forearm support low keyboard and vertical mouse design may benefit in musculoskeletal recurrent injuries. Use of lubricating eye drops, PUFA supplements and avoidance of CLs and treating any other preexisting ocular surface disorder yield benefit in maintaining healthy ocular surface and preventing related symptoms. The Role of frequent work breaks from the continuous VDT exposure cannot be underrated as it prevents cumulative work induced visual fatigue, ocular surface damage and musculoskeletal injury/strain; all at the same time. Therefore being an outcome of parallel and overlapping multi- factorial causes, it mandates multi-faceted critical analysis, tailored intervention for an effective prevention and treatmen