Children with Down's Syndrome or immunocompromised newborn babies, infants and children under the age of 24 months at the beginning of the RSV season have been recently added to those with an indication for the use of prophylactic Palivizumab. Here, we describe these new indications in the following sections. In addition, respiratory conditions such as underlying respiratory disease and chest deformity, as well as the risk of exposure to RSV (assessed
by prevalence in the geographical region or incidence in that particular the hospital, and the presence or absence of siblings), should also be taken into account.