Most epileptologists consider surgical manage-ment as second line therapy for patients with intrac-table seizures.
39
This is especially true for patients
with drug-resistant temporal lobe epilepsy (TLE), for
whom temporal lobectomy can represent an effective
treatment option. A randomized control trial found
that 58% of patients randomly allocated to surgery
for temporal lobe resection did not present with any
seizures which impaired consciousness after one year,
compared to 8% in the treatment arm receiving the
optimum medication regimen (P , 0.001).
20
A multi-center study which followed 339 patients with epilepsy
for 2 years post-operatively showed that temporal
surgery in this patient population: 68% of the patients
who received temporal lobectomies experienced sei-zure remission for 2 years, compared to 50% of the
patients who underwent extratemporal resections.
40
Another non-randomized controlled study which fol-lowed up patients with refractory seizures, assigned
either to surgical treatment or continued drug therapy,
found that 44.6% of 242 patients with pharmacoresis-tant TLE who received surgery were seizure-free for
12 months, compared to 4.3% of those who received
AEDs only (P , 0.001).
41
It should be emphasized,
however, that not all patients with TLE have the same
probability of achieving seizure freedom through
temporal lobe resection. A meta-analysis of 83 studies
including 7,343 patients undergoing epilepsy surgery
showed that the proportion of patients experiencing
was highest in those who underwent temporal lobe
tion of patients undergoing occipital, parietal or
frontal lobe resections demonstrated post-operative
seizure freedom (46%, 46% and 27% respectively).
42
It should be noted that post-operative seizure free-dom for the first few years following surgery might
not persist long-term. Isolated relapses can still occur
many years after the procedure, with a probabilit
Most epileptologists consider surgical manage-ment as second line therapy for patients with intrac-table seizures.39This is especially true for patients with drug-resistant temporal lobe epilepsy (TLE), for whom temporal lobectomy can represent an effective treatment option. A randomized control trial found that 58% of patients randomly allocated to surgery for temporal lobe resection did not present with any seizures which impaired consciousness after one year, compared to 8% in the treatment arm receiving the optimum medication regimen (P , 0.001).20A multi-center study which followed 339 patients with epilepsy for 2 years post-operatively showed that temporal surgery in this patient population: 68% of the patients who received temporal lobectomies experienced sei-zure remission for 2 years, compared to 50% of the patients who underwent extratemporal resections.40Another non-randomized controlled study which fol-lowed up patients with refractory seizures, assigned either to surgical treatment or continued drug therapy, found that 44.6% of 242 patients with pharmacoresis-tant TLE who received surgery were seizure-free for 12 months, compared to 4.3% of those who received AEDs only (P , 0.001).41It should be emphasized, however, that not all patients with TLE have the same probability of achieving seizure freedom through temporal lobe resection. A meta-analysis of 83 studies including 7,343 patients undergoing epilepsy surgery showed that the proportion of patients experiencing was highest in those who underwent temporal lobe tion of patients undergoing occipital, parietal or frontal lobe resections demonstrated post-operative seizure freedom (46%, 46% and 27% respectively).42It should be noted that post-operative seizure free-dom for the first few years following surgery might not persist long-term. Isolated relapses can still occur many years after the procedure, with a probabilit
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