VasopressorsThe second resuscitation endpoint in SS/SS is the establishmentof a MAP of at least 65 mmHg. In SS/SS, there is animbalance between vasodilation and vasoconstriction. Accordingly,vasoactive medications are often required in septicpatients with hypotension (MAP <65 mmHg). Their purposeis to restore adequate arterial pressures and blood flow to vitalorgans. Below MAPs of 60 mmHg, coronary, renal and CNSautoregulation are lost and organ blood flow has a linear relationshipwith pressure.34 However, tissue perfusion can bemaintained at MAPs as low as 65 mmHg.35 As such, when
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