Recently, a randomized, controlled trial that included
20,211 trauma patients [ 28 ] showed that the routine
administration of tranexamic acid (loading dose of 1 g
over 10 min, then infusion of 1 g over 8 hr) in
patients with hemorrhagic shock was associated with a
decreased mortality rate without an increase of
thromboembolic complications. Thus, tranexamic acid
should be included in the current management of
patients with traumatic hemorrhagic shock (Figures 1 and 2)
the opimal effect of this drug is observed in the first 3 hr of use