Villa Sant'Antonio (Sant'Antoni in Sardinian language) is a comune (municipality) in the Province of Oristano in the Italian region Sardinia, located about 70 kilometres (43 mi) north of Cagliari and about 25 kilometres (16 mi) east of Oristano. As of 31 December 2004, it had a population of 441 and an area of 19.2 square kilometres (7.4 sq mi). Villa Sant'Antonio borders the following municipalities: Albagiara, Assolo, Asuni, Mogorella, Ruinas, Senis.