cytochrome P450 (Teel & Huynh, 1998). Furthermore, caffeine
is metabolized through cytochrome P450 enzymatic path which
might cause a decrease in the revertants number, due to a competitive
inhibition (Weisburger, Dolan, & Pittman, 1998).
Thus, spent coffee extract compounds were capable of inhibiting,
of destroying or of avoiding DNA damage caused by
direct and indirect acting mutagens, and consequently, might
be linked with the prevention of earlier stages of carcinogenesis.