Furthermore, consumption of caffeinated coffee tended to improve serine phosphorylation of Akt after insulin stimulation, but again, it did not reach statistical significance. A microarray analysis revealed that among the genes analyzed, 285 genes in the caffeinated coffee mice, 247 in the decaffeinated coffee mice, and 169 in the green coffee mice were differentially expressed in skeletal muscle [15]. Among the downregulated genes were several associated with cellular stress and inflammation as well as genes known to be upregulated in human diabetic patients.