n conclusion, we were able to reach an adequate volume replenishment in all but 1 patient who needed fluid resuscitation for a MAP less than 65 mm Hg. The amount of fluids administered during the first 6 hours was on average 5.5 L (Table 2). The goal of a lactate clearance at least 10% was reached in 70.3% of cases.
With lung sonography, we recorded a US pattern of interstitial syndrome in 13 (27.7%) of 47 patients. In 4 of these cases, this pattern was already present at the time of enrollment and was considered clinically nonspecific, whereas in the remaining 9 cases, it appeared at some point during treatment. This US finding was considered as a preclinical sign of pulmonary fluid overload, and further investigations were ordered (ie, echocardiography) to guide subsequent treatment. In 3 of 9 cases, a reduced cardiac output was identified by echocardiography, and inotropes were started under supervision of a cardiologist or intensive care unit specialist. In the remaining 6 cases, fluid administration was reduced, and vasopressors were started.
On 47 patients treated, we observed 4 cases of clinically overt pulmonary edema. Two of these patients required noninvasive ventilation, one required endotracheal intubation, and the fourth died in the ED.
Overall mortality was 34% at 28 days and 38.3% at 60 days. Mortality at 28 days was 38.2% for septic shock with hypotension and 23% for cryptic shock. Mortality at 60 days was 44.1 for septic shock with hypotension and 23% for cryptic shock.
n conclusion, we were able to reach an adequate volume replenishment in all but 1 patient who needed fluid resuscitation for a MAP less than 65 mm Hg. The amount of fluids administered during the first 6 hours was on average 5.5 L (Table 2). The goal of a lactate clearance at least 10% was reached in 70.3% of cases.With lung sonography, we recorded a US pattern of interstitial syndrome in 13 (27.7%) of 47 patients. In 4 of these cases, this pattern was already present at the time of enrollment and was considered clinically nonspecific, whereas in the remaining 9 cases, it appeared at some point during treatment. This US finding was considered as a preclinical sign of pulmonary fluid overload, and further investigations were ordered (ie, echocardiography) to guide subsequent treatment. In 3 of 9 cases, a reduced cardiac output was identified by echocardiography, and inotropes were started under supervision of a cardiologist or intensive care unit specialist. In the remaining 6 cases, fluid administration was reduced, and vasopressors were started.On 47 patients treated, we observed 4 cases of clinically overt pulmonary edema. Two of these patients required noninvasive ventilation, one required endotracheal intubation, and the fourth died in the ED.Overall mortality was 34% at 28 days and 38.3% at 60 days. Mortality at 28 days was 38.2% for septic shock with hypotension and 23% for cryptic shock. Mortality at 60 days was 44.1 for septic shock with hypotension and 23% for cryptic shock.
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